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Ref ID: 37318
Ref Type: Journal Article
Authors: Guo, Jianxin
Wang, Weitao
Zhao, Kai
Li, Guangxing
He, Guanglin
Zhao, Jing
Yang, Xiaomin
Chen, Jinwen
Zhu, Kongyang
Wang, Rui
Ma, Hao
Xu, Bingying
Wang, Chuan-Chao
Title: Genomic insights into Neolithic farming-related migrations in the junction of East and Southeast Asia
Date: 2021
Source: American Journal of Biological Anthropology
Abstract: Objectives: We aim to detect demographic history and early farming-relatedmigration of the crossroad area in the junction of east Asia (EA) and southeastAsia (SEA).

Materials and methods: We collected and genotyped 87 individuals from 6 Tibeto-Burman and Austroasiatic-speaking populations including Bai, Pumi, Hani,Lahu, Wa, and Blang with nearly 700,000 genome-wide SNPs. We subsequently analyzed genetic structure and admixture using our merged dataset including both ancient and modern eastern Eurasians with PCA, ADMIXTURE,Refine-IBD, fstatistics and qpAdm.

Results: We observed population substructure within the studied Tibeto-Burman populations. The northern Tibeto-Burman groups (Bai and Pumi) had a predominant genomic legacy associated to millet-farming from North China and also high frequencies of Y-chromosomal haplogroup O2a2b1-M134 (xM117) and its sub-clades. By contrast, southern Tibeto-Burman groups (Lahu and Hani) had more than 60% genomic legacy associated to rice-farming, which is prevalent in present-day Tai-Kadai, Austronesian and Austroasiatic speaking populations. We observed strong genetic affinities between Austroasiatic populations in Yunnan (Blang and Wa) and mainland southeast Asia.

Discussion: Our study revealed that both demic migrations and cultural interactions from north to south and east to west since the Late Neolithic have shaped the genetic structure of populations at the crossroads of EA and SEA. The dominant genomic legacy associated with millet-farming in northern Tibeto-Burman populations indicates large-scale Neolithic migrations from the Upper-Middle YellowRiver Basin. The rice-farming expansion has deeply influenced the genetic profile ofboth southern Tibeto-Burman and Austroasiatic populations, suggesting migrationsfrom east to west via both inland and coastal routes.
Volume: 177
Page Start: 328
Page End: 342