Ref ID:
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35134 |
Ref Type:
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Journal Article |
Authors: |
Seedat, H. A.
van Wyk, C. W.
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Title: |
Submucous fibrosis in non-betel nut chewing subjects
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Date: |
1988
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Source: |
British Medical Journal (Clinical Research Education)
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Abstract: |
Six patients with the typical features of submucous fibrosis (SF) but without a history of betel nut chewing or an abnormal intake of chillies are described. All had palpable fibrous bands in their mouths and limited mouth opening as well as a variety of symptoms associated with SF. Biopsy specimens of the cheeks showed the classic features of SF, an atrophic epithelium and a very dense lamina propria. Also seen were hyperkeratosis, atypia and signet cell-like degeneration of the epithelium and chronic inflammation of the lamina propria. In 3 cases the fibrosis extended into the submucosa. As no reason for the disease could be demonstrated the question is asked whether people with a genetic predisposition can develop SF spontaneously.
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Date Created: |
6/28/2001
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Volume: |
16
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Number: |
1
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Page Start: |
3
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Page End: |
6
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