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Ref ID: 35054
Ref Type: Journal Article
Authors: Sharan, R. N.
Wary, K. K.
Title: Study of unscheduled DNA synthesis following exposure of human cells to arecoline and extracts of betel nut in vitro
Date: 1992
Source: Mutation Research
Abstract: Aqueous, acetic acid, hydrochloric acid and ethanol extracts of betel nut (Areca catechu L.) have been found to induce unscheduled DNA synthesis in Hep 2 cells obtained from human larynx carcinoma, in vitro. Different concentrations of extracts of betel nut induced dose dependent unscheduled DNA synthesis in Hep 2 cells. Together with the viability of the Hep 2 cells, our results indicate that the aqueous and acetic acid extracts of betel nut induce relatively more unscheduled DNA synthesis than the hydrochloric acid and ethanol extracts and arecoline. The carcinogenic potency of raw and unprocessed betel nut of North-East India used in this study is discussed.
Date Created: 6/28/2001
Volume: 278
Number: 4
Page Start: 271
Page End: 276