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Ref ID: 35045
Ref Type: Journal Article
Authors: Sinha, A.
Rao, A. R.
Title: Induction of shape abnormality and unscheduled DNA synthesis by arecoline in the germ cells of mice
Date: 1985
Source: Mutation Research
Abstract: The ability of arecoline, an alkaloid of betel nut, to induce abnormality in the shape of sperm heads and unscheduled DNA synthesis (UDS) in the early spermatid stages of Swiss albino mice was studied. Treatment of mice with arecoline at the dose levels of 20, 40 and 80 mg/kg elicited dose-related increase in the number of abnormal sperm heads, as well as the unscheduled incorporation of [3H]thymidine into the DNA of early spermatids. Such increase in the production of abnormally shaped sperms and UDS response of the early spermatids following arecoline treatment expressed its genotoxic potential in the mouse germ cells. PMID- 3935921
Date Created: 6/28/2001
Volume: 158
Number: 3
Page Start: 189
Page End: 192