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Ref ID: 37112
Ref Type: Journal Article
Authors: Larena, Maximilian
McKena, James
Sanchez-Quito, Federico
Bernhardsson, Carolina
Ebeo, Carlo
Reyes, Rebecca
Casel, Ophelia
Huang, Jin-Yuan
Pullupul, Hagada Kim
Guilay, Dennis
Reyes, Jennelyn
Pir Allian, Fatima
Mori, Virgilio
Sue Azarcon, Lahaina
Manera. Alma
Terando, Celito
Jamero, Lucio
Sireg, Gauden
Manginsay-Tremedal, Renefe
Labos, Maria Shiela
Vilar, Richard Dian
Latiph, Acram
Saway, Rodelio Linsahay
Marte, Erwin
Magbanua, Pablito
Morales, Amor
Java, Ismael
Reveche, Rudy
Barrios, Becky
Burton, Erlinda
Salon, Jesus Christopher
Kels, Ma. Junaliah Tuazon Kels
Alabano, Adrian
Cruz-Angeles, Rose Beatrix
Molanida, Edison
Granehäll, Lena
Vicente, Mário
Edlund, Hanna
Loo, Jun-Hun
Trejaut, Jean
Ho, Simon Y. W.
Reid, Lawrence
Lambeck, Kurt
Malmström, Helena
Schlebusch, Carina
Endicott, Philip
Jakobsson, Mattias
Title: Philippine Ayta possess the highest level of Denisovan ancestry in the world
Date: 2021
Source: Current Biology
DOI: 10.1016/j.cub.2021.07.022
Abstract: Multiple lines of evidence show that modern humans interbred with archaic Denisovans. Here, we report an account of shared demographic history between Australasians and Denisovans distinctively in Island Southeast Asia. Our analyses are based on ∼2.3 million genotypes from 118 ethnic groups of the Philippines, including 25 diverse self-identified Negrito populations, along with high-coverage genomes of Australopapuans and Ayta Magbukon Negritos. We show that Ayta Magbukon possess the highest level of Denisovan ancestry in the world—∼30%–40% greater than that of Australians and Papuans—consistent with an independent admixture event into Negritos from Denisovans. Together with the recently described Homo luzonensis, we suggest that there were multiple archaic species that inhabited the Philippines prior to the arrival of modern humans and that these archaic groups may have been genetically related. Altogether, our findings unveil a complex intertwined history of modern and archaic humans in the Asia-Pacific region, where distinct Islander Denisovan populations differentially admixed with incoming Australasians across multiple locations and at various points in time.
Volume: 31
Number: 19
Page Start: 4219
Page End: 4230