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Ref ID: 35098
Ref Type: Journal Article
Authors: Patel, R. K.
Trivedi, A. H.
Jaju, R. J.
Adhvaryu, S. G.
Balar, D. B.
Title: Ethanol potentiates the clastogenicity of pan masala--an in vitro experience
Date: 1994
Source: Carcinogenesis
DOI: https://doi.org/10.1093/carcin/15.9.2017
Abstract: The significance of the interaction between alcohol and tobacco in causing head and neck cancers is well documented. Our previous reports on in vitro studies using aqueous and organic extracts as well as cytogenetic studies among pan masala consumers have conclusively shown the genotoxic potential of pan masala--a dry mixture of the areca nut lime, catechu, unspecified flavouring agents, etc., often containing tobacco in it and is widely consumed in India. Now in the present report, the clastogenic effect of ethanol and pan masala in different combinations was evaluated on Chinese hamster ovary cells utilizing chromosome aberration (CA) frequency as an endpoint. An ethanol concentration of up to 2.0% had no effect on CA/cell value. The low dose continuous treatment and high-dose short-term pre-, post- and simultaneous treatment of ethanol and aqueous extract of pan masala with and without tobacco yielded dose-dependent elevations in CA frequency, compared to any of these two substances alone. Thus, these results provide evidence that alcohol consumption may potentially increase the risk of oral cancer among pan masala chewers.
Date Created: 6/28/2001
Volume: 15
Number: 9
Page Start: 2017
Page End: 2021

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