Ref ID:	35067
Ref Type:	Journal Article
Authors:	Wary, K. K. Sharan, R. N.
Title:	Aqueous extract of betel-nut of north-east India induces DNA-strand breaks and enhances rate of cell proliferation in vitro. Effects of betel-nut extract in vitro
Date:	1988
Source:	Journal of Cancer Research and Clinical Oncology
Abstract:	An aqueous extract of betel-nut has been found to be able to induce strand breaks in DNA of mouse kidney cells in vitro. It has been also found to be able to enhance the rate of cell division at a dose of 100 micrograms/ml while a higher dose of 250 micrograms/ml was extremely toxic to the cells. Compared with arecoline (10 micrograms/ml), the aqueous extract of betel-nut seems to be a more potent carcinogen to mouse kidney cells in vitro.
Date Created:	6/28/2001
Volume:	114
Number:	6
Page Start:	579
Page End:	582