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Ref ID: 35004
Ref Type: Journal Article
Authors: Dave, B. J.
Trivedi, A. H.
Adhvaryu, S. G.
Title: Variations in centromeric heterochromatin among patients with pre malignant and malignant oral diseases
Date: 1991
Source: International Journal of Cancer
DOI: 10.1002/ijc.2910480313
Abstract: Polymorphism of heterochromatic regions of chromosomes 1, 9 and 16 was studied in 60 oral cancer patients, in 40 patients with oral submucous fibrosis (OSMF) and in 60 normal healthy subjects. The size heteromorphism was significantly greater (p less than 0.001) in chromosome I of the patients. Localization variants were also significantly more frequent among the patients (p less than 0.05 for OSMF and less than 0.001 for oral cancer patients). The C-band heteromorphism patterns remained comparable in OSMF and in oral cancer patients, with chromosome I being the most frequently involved. On correlating the tobacco/areca-nut chewing habit with the presence of C band heteromorphism, we observed that C-band heteromorphism was present in 89% of the habit-free oral cancer patients and 80% of the OSMF patients with relatively shorter exposure to this habit, i.e. less than 5 years. This signifies that genetic factors are important in the causation of oral precancerous and cancerous conditions and that polymorphism of the heterochromatic regions does appear to play a role in these conditions.
Date Created: 6/28/2001
Volume: 48
Number: 3
Page Start: 386
Page End: 389